Idelalisib is a PI3K-delta inhibitor with potential immunomodulatory and antineoplastic activities. Inhibiting the production of the second messenger phosphatidylinositol-3,4,5-triphosphate (PIP3), inhibiting the activation of PI3K signal transduction pathway, thus inhibiting the proliferation, movement and survival of cancer cells. Unlike other homotypes of PI3K, PI3K-delta is mainly expressed in hematopoietic lineage.
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